Some of the more interesting papers in Pubmed Central that reference Valentine's Day

Earlier this AM I posted to twitter a brief comment about articles in Pubmed Central that reference Valentine's Day.

Yes, there are 120 papers that come up in Pubmed Central w/ a search for "Valentine's Day"shar.es/fSi8b
— Jonathan Eisen (@phylogenomics) February 14, 2012

Kay Thaney's response caught my eye b/c she called attention to some of the more interesting papers from my link:

@phylogenomics @David_Dobbs uplifting. among results, "sweet nothings?", "parasuicide","diabetes bingo" + "HIV epidemics". #loveisintheair
— Kaitlin Thaney (@kaythaney) February 14, 2012

So I thought I would post a few of the links here:

• Temporal Patterns of Happiness and Information in a Global Social Network: Hedonometrics and Twitter
• What's in a message? Delivering sexual health promotion to young people in Australia via text messaging
• St Valentine’s Day
• Priming the Holiday Spirit: Persistent Activation due to Extra-Experimental Experiences
• Diabetes Bingo: Research Prioritization with the Filipino Community
• A new national holiday? My vote’s for World Toilet Day
• A case of selective impairment of encyclopaedic numerical knowledge or ‘when December 25th is no longer Christmas day, but ‘20 + 5’ is still 25’
• ‘Finish your soup’: Counterproductive effects of pressuring children to eat on intake and affect
• Bio-bling: making jewellery from human tissue
• Explicit ads seek to halt rise in sexual diseases
• The physician as erotomanic object.

Enjoy ...

Draft post cleanup #7: Scamming Pubmed Central Deposition Rules

Yet another post in my "draft blog post cleanup" series.  Here is #7, from February this year.

I continue to be a bit annoyed by the Pubmed Central system for depositing your own papers there.  Well, actually, not annoyed with the existence of the system.  But am annoyed that you can only do it if you have an NIH grant ID associated with the paper you are depositing.  I am tempted to set up a system for sharing NIH grant IDs that would allow non NIH funded researchers to scam the system and to get their papers into Pubmed Central.  Almost certainly, people at NIH would not like this, but not sure whether this would be considered "illegal" or just "annoying".

And I am still unclear as to why Pubmed does this.  Genbank is NIH funded but will take sequences from any researcher no matter the source of funding for the work.  Anyway - I have not set up a NIH grant ID sharing system but if you want to submit an article to Pubmed Central and do not have an NIH grant ID, you might want to just ask someone who has one for a grant covering a similar topic at a similar time period.  I do not think NIH would figure out that the grant did not actually fund your work.  And you could even use the NIH grant search engine that pops up when you use the manuscript submission system or search Pubmed directly.  Not that I would recommend anyone break their rules or anything like that.

Fun with Pubmed central - first paper describing #HeLa cells - Note @rebeccaskloot

Last year, Rebecca Skloot came to Davis to talk about her book "The Immortal Life of Henrietta Lacks".  Note - if you have not read the book - what f*$ing rock have you been hiding under?  It is in my opinion the best non fiction book I have ever read.  Seriously.  Not the best science book. The best non fiction book of any kind.  And I am not alone in this feeling as it has won a bazillion positive reviews and awards.   In summary - it tells three stories - the story of the isolation of HeLa cells, the story of the woman from whom those cells came, and the story of Skloot learning the other two stories.

Anyway - I somehow managed to get her to come to UC Davis to give a talk last year just as the book was going viral.  In preparation for Skloot's visit I decided to do some sort of "open access" schtick and looked into how many papers about HeLa cells were in Pubmed Central.  Pubmed Central is a database of papers for which the full text is available at no charge.  After this mini-research and after interacting with Rebecca over the last year and seeing the well deserved recognition of her book, I have been a bit fascinated about how much of the literature surrounding studies of HeLa cells is openly and/or freely available.

So today I decided to see what was the earliest HeLa paper that was freely available on PubMed Central.  And I managed to find a good one: Studies on the propagation in vitro of poliomyelitis viruses. IV. viral multiplication in a stable strain of human malignant epithelial cells (strain hela) derived from an epidermoid carcinoma of the cervix. William F. Scherer, Jerome T. Syverton, and George O. Gey.  J Exp Med. 1953 May 1; 97(5): 695–710.

I believe this was the first full paper published discussing HeLa cells.  Nice short title by the way. Anyway - good to see it in Pubmed Central.

I note  - I could not find in Pubmed Central the meeting abstract about HeLa cells which was published in 1952 but I did find it from Cancer Research's online archive here.  I have copied the abstract below, for you HeLa history buffs out there:

TISSUE CULTURE STUDIES OF THE PRO-
LIFERATIVE CAPACITY OF CERVICAL
CARCINOMA AND NORMAL EPITHE-
LIUM. George O. Gey,Ward D. Coffman*
and Mary T. Kubicek *(Departments of
Surgery and Gynecology, Johns Hopkins
Hospital and University, Baltimore 5, Md.

This is a report of an evaluation in vitro of the
growth potential of normal, early intra-epithelial,
and invasive carcinoma from a series of cases of
cervical carcinoma. Comparable cytological and
tissue culture studies were actually carried out on
selected biopsies of normal and neoplastic areas of
the same cervix. Thus far, only one strain of epi-
dermoid carcinoma has been established and
grown in continuous roller tube cultures for al-
most a year. It grows well in a composite medium
of chicken plasma, bovine embryo extract, and
human placenta! cord serum. The autologous nor-
mal prototype is most difficult to maintain under
comparable cultural conditions. Most of the tissue
from other cases showed rapid keratinization of
the cells grown in cultures whether from normal
or neoplastic areas. Some of the hormonal aspects
of the problem will be discussed.

Anyway - if you are interested in HeLa and/or The Immortal Life of Henrietta Lacks, you may find it interesting to check out these early papers on the topic such as the ones described above.  Here are a few more that are from the early era and are freely available:

• Active Immunization Against Poliomyelitis 
• Use of Human Cancer Cells to Diagnose Poliomyelitis
• Poliomyelitis Viruses in Tissue Culture
• THE BINDING OF PENICILLIN IN RELATION TO ITS CYTOTOXIC ACTION : III. THE BINDING OF PENICILLIN BY MAMMALIAN CELLS IN TISSUE CULTURE (HELA AND L STRAINS)
• GROWTH CHARACTERISTICS OF POLIOMYELITIS VIRUS IN HELA CELL CULTURES: LACK OF PARALLELISM IN CELLULAR INJURY AND VIRUS INCREASE
• The Viral Range in Vitro of a Malignant Human Epithelial Cell (Strain HeLa, Gey): I. Multiplication of Herpes Simplex, Pseudorabies, and Vaccinia Viruses

Pubmed Central is a rich resource not just for accessing scientific papers but for learning about science history too.  It is a good thing that articles in Pubmed Central are available at no charge and here's hoping that sometime soon that past and present and future science papers will be more readily available to all.

UPDATE ----------
John Hogenesch from U. Penn made a nice figure of relevance and agreed to let me post it:

And he comments "You can see several things, Nixon's "war on cancer" in the early 70s and the dawn of the cell/molecular biology age in the 80s and expansion in the 90s."

Thanks John ...