Well, just got back from Synthetic Biology 5.0 at Stanford. I don't really have time to do a thorough job with a blog post but I will try to fill in some details here.
1. Got invited by Natalie Kuldell in April to participate in an education workshop for the meeting. Eventually said yes, but only after deciding to not go to the Earth Microbiome Meeting in Beijing. I said yes in part b/c it was close by home but also b/c of the people Natalie invited to be on the panel. She wrote in the invitation email:
Other panelists who have confirmed their participation in this session are from Understanding Science/Understanding Evolution (Juday Scotchmoor), Nature Education (Ilona Miko), Science for Citizens (Darlene Cavalier), GenSpace (Ellen Jorgenson), and Hong Kong University of Science and Technology (King Chow).And well, of the ones I knew on the list, they all were great.
2. Had a conference call (very brief) in June to discuss the session.
3. Headed out to Stanford very late Tuesday night - and thus missed the Slam session that night. I got to my hotel at about 1:30 AM.
4. I woke up early enough to hop on my bike and ride on over to the meeting. I was a PhD student at Stanford and had brought my bike in the hopes of going for some rides around town. I took some pics on the way in:
Got to the meeting and of course posted a few tweets
- RT @chofski: Follow coverage of Synthetic Biology 5.0 conference using the hashtag #synbio5
- RT @chofski: Apparently there is a live stream of SB5.0 over the Internet. Maybe check out the home page if you're interested? #synbio5
- phylogenomics: Just got to #synbio5 at Stanford on my bike from my hotelhttp://t.co/9vhhN8t http://t.co/8FX6PAD
- phylogenomics: Drew Endy encouraging crowd to draw some pictures on their ID badges - here is Clyde Hutchison's effort #synbio5 http://t.co/PfnADE9
- phylogenomics: Arrived at #synbio5 - Drew Endy opening it all uphttp://t.co/o0IirDC http://t.co/jul8xLY
- phylogenomics: Saw Eric Lander - Ham Smith - Clyde Hutchison - Adam Arkin - Pam Silver all up front #synbio5 http://t.co/WpRmwHs
- phylogenomics: Endy refs quote of Eric Lander's from after human genome proj: "Genome - bought the book - hard to read" twitpic.com/5bxgb7 #synbio5
- phylogenomics: John Glass: he is very proud of being involved in making 1st synthetic genome - if he were a goat he would infect himself w/ it #synbio5
- phylogenomics: Lander asks "What are the ret challenges of synthetic biology" - need a list like Hilbert's math challenges to shape field” #synbio5
- phylogenomics: John Glass discussing history of synthetic genomics #synbio5and why they started working on mycoplasmas http://t.co/aVuNino
- phylogenomics: Lots of the people in this session at #synbio5 make spoof music videos http://t.co/uYE5WuP
- phylogenomics: RT @drtomellis: #synbio5 First shout out for Gibson Assembly for SB5.0. There will be many more this week. http://t.co/AgCSJnz
- phylogenomics: Pam Silver says big challenge of synthetic biology is to make it open to all #synbio5 - need to tolerate failure http://t.co/mKvX1m6
- phylogenomics: Lander refs Botstein comment on genome - like a book in foreign language - proof of understanding =writing a book in that language #synbio5
- phylogenomics: RT @Erika_Check: P Silver: syn bio needs to have "more of a tolerance for failure" than traditionally exists in other disciplines #synbio5
- phylogenomics: RT @drkahaynes: Loving Drew Endy's earlier quote 'Can write DNA, but not much to say.' #synbio5
- phylogenomics: Maitreya Dunham suggests need to carry out horizontal transfer of genes on global scale to test all functions #synbio5 #metagenomics
- phylogenomics: Love how at #synbio5 Drew Endy is delivering panel ??s by walking index cards to Eric Lander http://t.co/1DjiWIQ http://t.co/bZePTBW
- phylogenomics: RT @peccoud: RT @synthaes: how do we keep synthetic genomics open source? vital - jef boeke #synbio5 So many aspects: data, software, sequences
- phylogenomics: Love how speaker at #synbio5 trying to push for power of synbiology and Eric Lander keeps saying "The genetics told us that" #gogenetics
- phylogenomics: Eric Lander is one of the best panel moderators I have ever seen - except maybe Robert Krulwich - #synbio5 - great job pushing discussion
- drkahaynes: ITA He's great RT @phylogenomics: Eric Lander is one of the best panel moderators I have ever seen #synbio5
- phylogenomics: Pam Silver says that the virome is fascinating and needs more looking into #synbio5
- phylogenomics: Lander has just gone through effective population size Vs. Selective coefficients #math-at-9am #synbio5
- phylogenomics: RT @peccoud: #synbio5 John Glass, we have no idea how to design a genome? Would studying evolution help? Not sure.
- phylogenomics: The synthetic biology express - Drew Endy hand delivering questions to panel #synbio5 http://t.co/soIpd3c
- phylogenomics: Lander fo abstracts for future science - some awesome ones - Pam Silver says "photosynthetic humans developed for travel to mars" #synbio5
- phylogenomics: Alica Jackson from DARPA announcing DARPA is getting into synthetic biology in a big big big way w/ "Living Foundries Program" #synbio5
Then there was a break and I got to talk to a few key people including Alicia Jackson from DARPA who I have been playing a bit of phone tag with. I also got to meet some people I only knew online/via twitter like Erika Hayden.
And then back in to the next session and more tweeting:
And then back in to the next session and more tweeting:
- phylogenomics: A RockStar of science George Church has arrived #synbio5http://t.co/ojGBgbo
- phylogenomics: George Church says this is his conflict of interest slide #synbio5http://t.co/pVSkeKg
- phylogenomics: George Church lists 35 next gen sequencing companies and says "they are all my favorite so I am not going to pick one to win" #synbio5
- phylogenomics: George Church discussing making antibody & antigen libraries from individual people #synbio5 - is there anything he doesn't do? #synbio5
- phylogenomics: RT @Erika_Check: No funding details avail on DARPA Living Foundries prog; more may be released at "industry day" in DC area on June 28#synbio5
- phylogenomics: RT @rob_carlson: #synbio5 Alicia Jsckson announces DARPA Living Foundries Program "custom, distributed, on demand manufacturing". Here comes the #bioeconomy.
- phylogenomics: Imagine something important for sequencing or synthetic biology: George Church almost certainly does it #synbio5
- phylogenomics: So many more tweeters at #synbio5 than at most meetings I go to - very interesting following stream - wish more meetings were like this
- phylogenomics: George Church creating an incredible diversity of synthetic sensors to detect all sorts of conditions #synbio5
- phylogenomics: Church: using caDNAno (see http://t.co/yFM24Qq) with aptamer and antibody based logic systems in leukemia therapy #synbio5
- phylogenomics: Church thinks Timothy Ray Brown leukemia Treatment will be landmark b/c it cured leukemia and made HIV resistant #synbio5
- phylogenomics: Church using TAL effectors as designer gene regulators - see Nature Biotech Zhang et al 2011 #synbio5
- phylogenomics: Church - working with Zhang and UCSD on sequencing hiPS lines from multiple labs #synbio5
- phylogenomics: Church thinks the ultimate is going to be full in situ characterization methods to study cancer- sounds like metagenomics to me #synbio5
- phylogenomics: Next gen reading and writing of omes is what Church is about#synbio5
- phylogenomics: Crowd is packed here for #synbio5 http://t.co/iSd1ig6http://t.co/sD5Vxrh
- phylogenomics: Church wants to do fluorescent in situ RNA sequencing #synbio5- note he says this was original goal of his development of next gen methods
- phylogenomics: Now up Alice Ting from MIT discussing technologies for detecting and analyzing proteins in living cells #synbio5
- phylogenomics: Ting: there is a need for new protein labeling methods especially ones that add chemicals to specific amino acids of proteins #synbio5
- phylogenomics: Ting: developed probe incorporation mediated by enzymes method #synbio5
- phylogenomics: I'm not going to be able to keep up w/ Ting's talk at #synbio5 so suggest looking here http://t.co/HxJvn9w
- phylogenomics: RT @rob_carlson: #synbio5 Alice Ting: Oh, cool: computational design of ligase for connecting fluorophore to recombinant tag in vivo (ref JBC Fujiwara 2010?)
- phylogenomics: RT @leonidkruglyak: At least it's live-tweeted RT @DrewEndy: Ting's talk not webcast due to IP issues. 100% appropriate to hassle me.@biobricks #synbio5
- phylogenomics: Ting's work is fascinating - but talk a bit too focused on tech details & not the big picture of what this could be used for #synbio5
- phylogenomics: Ting targeting enzymes to one cellular compartment that allow biotin attachment to proteins nearby that enzyme #synbio5
- phylogenomics: Ting's method allows one to biotin label all proteins in particular regions of a cell and then can purify these and do Proteomics #synbio5
- phylogenomics: RT @rob_carlson: @DrewEndy @biobricks #synbio5 "Ting's talk not webcast due to IP issues." How is this not a public talk that would count as a disclosure?
- phylogenomics: Now up Trent Nothern who says he views DNA as a bunch of goo that regulates interesting small molecules #synbio5
- phylogenomics: Northern: developing high throughput and cheap methods for characterizing small molecules #synbio5
- phylogenomics: Trent Northen doing very good job describing methods behind his work on metabolite analysis #synbio5 - also has good methods slides
- phylogenomics: Northen: feeding organisms various stable isotope containing molecules and then can watch uptake and use of these with mass spec #Synbio5
- phylogenomics: Lesson from #synbio5 one can have all the toys in the world, but all that gets you is data; turning that to knowledge is difficult
- phylogenomics: RT @ericmjl: In mass spec, the 'colors' are isotopes. #synbio5
- phylogenomics: Northen describing his development of NIMS which basically allows one to get 2D plot of mass spec data from sample #synbio5
- phylogenomics: RT @Erika_Check: for those following #synbio5: my curtain raiser on the meeting: http://bit.ly/iGd4AQ
Then I did indeed go for a bike ride (at lunch time)
- phylogenomics: To skip out on part of #synbio5 for a bike ride I am wearing my schwag Amyris shirt http://t.co/092US3v http://t.co/7Rkscg8
I rode up alpine road - not too far - maybe 8-9 miles up and then 8-9 miles back. But it was nice to get out and back on the roads of my semi-youth.
And then back to the meeting (after changing shirts ...) where I caught Pam Silver talking (note - Silver is one of my favorite people in biology - brilliant - really funny - down to Earth - etc; second note - she grew up in the area near the meeting and told some good stories outside in the breaks about skateboarding around Stanford Campus).
- phylogenomics: RT @drtomellis: #synbio5 Growth Laws for bacteria talk is fantastic example of how a model-based talk can be pitched to a wide audience.
- phylogenomics: Pam Silver discussing carboxysomes in Cyanobacteria #synbio5says they are precursors of Chloroplast tho not true - modern cyanos are modern
- phylogenomics: Silver says cyanos require carboxysomes to grow and survive and wants to transfer carboxysomes to other taxa #synbio5
- phylogenomics: Silver using protein engineering and synthetic biology to try to get E. Coli to make hydrogen #synbio5
- phylogenomics: RT @rob_carlson: #synbio5 @pamsterdance shows hacked carbon fixing E coli
- phylogenomics: just discovered that speaker Pam Silver is on twitter :@pamsterdance h/t to @rob_Carlson #synbio5
- phylogenomics: Silver excited hydrogen production working better and better: says maybe "we will soon blow up my chairman's lab next door" #synbio5
- phylogenomics: RT @bacteriality: @phylogenomics A functional carboxysome-like compartment won the best new part, natural 2010 iGEM: http://t.co/eyJqkwn#UMN #synbio5
- phylogenomics: Silver set up system where in mixed cultured growth of E. Coli depended on photosynthesis by a cyano #synbio5
- phylogenomics: Silver: lots of photosynthetic animals such as sea slug, Jellyfish, Jolly Green Giant (says size saying should have been small) #synbio5
- phylogenomics: Silver injected cyanos into zebrafish embryos and the cyanos do just fine #synbio5 though fish do not then grow on light alone
- phylogenomics: Speaker discussing MinE and MinD proteins in E. Coli ... i always thought MinE should have been named MorK #synbio5 #geekhumor
- phylogenomics: RT @thisischristina: I propose that the remaining #synbio5sessions are all moderated by Eric Lander and take place at the pool.
I then stopped tweeting because my phone battery died and I had to get back to my hotel to take a shower. So I took a little break. And then returned for the poster session where I really only ended up seeing one poster, because it was so awesome:
- phylogenomics: Ok this is brilliant #art-science - poster at #synbio5 Karmella Haynes #fb http://t.co/D5ubPP6 http://t.co/iwgzhqO
I spoke to Karmella for a while and then to some others. And eventually I headed back to the hotel to crash because I was pretty beat. I had dinner and then went back to my room and blogged about Karmella:
- phylogenomics: More art & science - hand painted poster at Synthetic Biology#synbio5 - by Karmella Haynes http://ff.im/-FT3Og
And went to sleep.
Then, at 4 AM the hotel alarm went off waking me up. It eventually went off again while I was still trying to get my act together to get out of the room. And then it went off again a few minutes later. I did not really get back to sleep. So of course I posted something
- phylogenomics: Thanks Westin in Palo Alto, the two false fire alarms at ~4 AM made my day; though one good thing:they did prove their alarms work #synbio5
I eventually went downstairs and decided to check out of the hotel and skip the Friday part of the meeting because I was just dragging. So I checked out and complained about the alarm and got a free breakfast. So I left my bike and suitcase at the front desk and went to breakfast where I saw Eric Lander also eating. I did not want to bother him too much but I stopped by and said hello and then asked if he has seen the painted poster and he had not. So I showed him pics and he asked if I could email him more detail because he wanted to invite Karmella to display her work at the Broad. Eventually I drove on to campus to go to the AM talks.
I got there in the middle of a talk
So I went to the posters again and took some more pics of Karmellas poster so you could see the canvas.
- phylogenomics: More pics of hand painted poster from #synbio5 http://ff.im/-FUnFd
I also got a picture of someone taking pictures of all the posters - which seemed a little lame. I note I asked for permission from Karmella before taking pictures of her poster.
I then went to a talk or two and spent a bunch of time sitting outside talking to various people. I pretty much always like meeting and talking to people over going to talks in overheated conference rooms (note to Stanford - if you want to host meetings in June get some f*$&% air conditioning in your rooms). Also note - it may not be the best idea in the world to put out lunch boxes in the sun at 10:30 AM.
I then went to a talk or two and spent a bunch of time sitting outside talking to various people. I pretty much always like meeting and talking to people over going to talks in overheated conference rooms (note to Stanford - if you want to host meetings in June get some f*$&% air conditioning in your rooms). Also note - it may not be the best idea in the world to put out lunch boxes in the sun at 10:30 AM.
- phylogenomics: Overheard at #synbio5 "the gap between rockets and terraforming is enormous"
- phylogenomics: Education session starting at #synbio5 ...
- ASU_iGEM: Following @phylogenomics after discussion about open source science. Twitter can be more informative than pubmed! #synbio5
- phylogenomics: Learning about "The Network for Citizen Science Projects & Resources" http://t.co/K7ikebf #synbio5
- phylogenomics: Listening to @scicheer discussing recruiting people into science#synbio5 #cheerleaders #NFL #citizenscience
- phylogenomics: Learning about GenSpace NYC http://t.co/cnQEPk1 #synbio5#scienceoutreach
The education session seemed to go quite well. I will try to post more on it later but I note it was videotaped and the video will supposedly be posted. It was great talking to the people on the panel and meeting some of the interested parties in the crowd.
And then after a group of us sat down for some sodas/tea and chatted. It was good to get a few minutes with people dedicated to outreach and education. And then to posters where I saw Marc Facciotti from Davis as well as a few other people I knew. And finally to home:
- phylogenomics: Schwag from #synbio5 very popular at home #Amyris #igemhttp://t.co/suZAzLX